Poly(ADP-ribose) polymerase 1 (PARP-1) is a protein involved in DNA repair and maintenance of genomic stability. PARP-1 is an enzyme that facilitates the addition of ADP-ribose units to target proteins in response to DNA damage, thereby orchestrating processes such as DNA repair, chromatin remodeling, and gene transcription. Dysregulation of PARP-1 activity has been implicated in various diseases, including cancer, inflammation, and neurodegenerative disorders. Research in the field of PARP-1 aims to understand its role in maintaining genomic integrity and to develop therapeutic strategies targeting PARP-1 for the treatment of various diseases.